Sodium Phosphate Tablets and Acute Phosphate Nephropathy

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Acute Phosphate Nephropathy

Acute phosphate nephropathy (APN) is defined as a clinical state characterized by kidney injury or failure following exposure to oral phosphate solutions for bowel cleansing before colonoscopy. Similar clinical situations were also seen with oral or intravenous phosphate replacement during hypophosphotemia treatment. The exact frequency was unknown but it has been reported more frequently in re...

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Acute phosphate nephropathy.

PURPOSE OF REVIEW Acute phosphate nephropathy (APN) has been identified in renal biopsy specimens of patients exposed to oral sodium phosphate (OSP) bowel purgatives. Biopsy confirmed cases presented with bland urinary sediment, low-grade proteinuria, and varying degrees of creatinine elevation. Prospective identification of APN is difficult in that definitive diagnosis requires renal biopsy, a...

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Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure.

The findings of diffuse tubular injury with abundant tubular calcium phosphate deposits on renal biopsy are referred to as nephrocalcinosis, a condition typically associated with hypercalcemia. During the period from 2000 to 2004, 31 cases of nephrocalcinosis were identified among the 7349 native renal biopsies processed at Columbia University. Among the 31 patients, 21 presented with acute ren...

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Renal failure due to acute phosphate nephropathy.

Case report of a 62-year-old woman who developed acute renal failure due to nephrocalcinosis, also called acute phosphate nephropathy, after large bowel cleansing in preparation for colonoscopy using oral sodium phosphate solution (Phosphoral, de Witt, Cheshire, UK). Subsequently her renal insufficiency resolved only partially resulting in stage 4 chronic kidney disease. In retrospect multiple ...

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Sodium dihydrogen phosphate Sodium dihydrogen phosphate monohydrate

1 These ingredients are nonmonograph except when used to prepare acidulated phosphate fluoride treatment rinses identified in § 355.10(a)(3) of this chapter. 201(p) of the Federal Food, Drug, and Cosmetic Act (the act), for which an approved application or abbreviated application under section 505 of the act and part 314 of this chapter is required for marketing. In the absence of an approved n...

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ژورنال

عنوان ژورنال: The American Journal of Gastroenterology

سال: 2009

ISSN: 0002-9270,1572-0241

DOI: 10.1038/ajg.2009.342